Differential Changes in Structural and Functional Connectivity:
The present longitudinal undertaking of the Connect Lab seeks to elucidate
the differences in how brain morphology and function change over time in
healthy older adults with and without memory complaints. Changes in functional
brain connectivity and brain structure will be measured with resting state
functional magnetic resonance imaging (RS-fMRI), diffusion weighted imaging
(DWI), and structural magnetic resonance imaging (MRI). The present study
aims to detect possible early biomarkers for Alzheimer's disease (AD) and
other dementias that may be present before there is an observable, detectable
decline in cognitive function.
Longitudinal Changes in Cognitive Function:
The lab seeks to discern the differential declines in cognitive function of individuals with Subjective
Cognitive Impairment (SCI) to controls and how these cognitive changes
relate to the changes in functional connectivity that are observed via fMRI.